Pockets of value
During our worldwide review of longitudinal datasets, we noted the richness of several datasets and opportunities they offer for transformative mental health research.
Our review was informed and guided by three key elements:
Wellcome’s vision for transformative mental health research
Input from stakeholders, particularly LEEs, who contacted us or participated in the ToC process
Our experience of screening and reviewing thousands of longitudinal datasets from around the world.
We categorised this richness into 19 ‘pockets of value’ for transformative mental health research. Check out the datasets included in each pocket of value in the drop-down menu below.
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In this pocket, we highlight 55 datasets with strong measurement of depression and anxiety.
23andMe - The Affective disorders, Environment, and Cognitive Trait (AFFECT) study
Adolescent Brain Cognitive Development (ABCD) Study
Amsterdam Born Children and their Development
Assessment from Preschool to Puberty—Longitudinal Epidemiological (APPLE) study in Hirosaki, Japan
Australian Temperament Project
Avon Longitudinal Study of Parents and Children (ALSPAC)
Born in Bradford: Better Start
Born in Guangzhou Cohort Study (BIGCS)
California Families Project (CFP)
Concord Health and Ageing in Men Project - CHAMP
Copenhagen Child Cohort Study (CCC2000)
Dutch ‘TRacking Adolescents’ Individual Lives’ Survey’; TRAILS
Environmental (E-Risk) Risk Longitudinal Twin Study
Generation Scotland (incl STRADL)
Growing Up in Scotland: Birth Cohort 1
Health and Employment After Fifty (HEAF) Cohort
Mental Health Services Data Set (MHSDS)
National Child Development Study (NCDS)
National Survey of Health and Development (NSHD)
Netherlands Study of Depression and Anxiety (NESDA)
NNDC (National Network of Depression Centers) Cohort
Norwegian Mother and Child Cohort Study (MoBa)
Pelotas (Brazil) Birth Cohort Study - 2015
Personality and Total Health Through Life
Quebec Longitudinal Study of Child Development
Resilience, Ethnicity & Adolescent Mental Health (REACH)
Study of Women's Health Across the Nation (SWAN)
Taiwan Birth Cohort Study (TBCS)
The Irish Longitudinal Study on Ageing (TILDA)
Trondheim Early Secure Study (TESS)
Twins Early Development Study (TEDS)
UKHLS: Understanding Society & BHPS
Western Australian schizophrenia high-risk e-Cohort
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In this pocket, we highlight 44 datasets with valuable data for psychosis research.
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Adolescent Brain Cognitive Development (ABCD) Study
Aetiology and Ethnicity in Schizophrenia & Other Psychoses (AESOP-10)
Australian Temperament Project
Butajira Course and Outcome Study for Severe Mental Illness
Copenhagen Child Cohort Study (CCC2000)
Danish High Risk and Resilience Study
Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Estonian Biobank of the Estonian Genome Center
European network of national schizophrenia networks studying gene-environment interactions (EU-GEI)
Feasibility and Acceptability of a Smartphone App to Assess Early Warning Signs of Psychosis Relapse
Fepsy early detection of psychosis
First Episode of Psychosis cohort
Generation Scotland (incl STRADL)
GROUP (Genetic Risk and Outcome of Psychosis)
iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology
International Research Programme on Psychosis in Diverse Settings (INTREPID)
Mauritius Child Health project
Mental Health Services Data Set (MHSDS)
National quality register for psychosis care (PsykosR)
Netherlands Mental Health Survey and Incidence Study (NEMESIS-II)
Netherlands Mental Health Survey and Incidence Study (NEMESIS)
North American Prodrome Longitudinal Study (NAPLS)
SCOPE: Studying the sociocultural context of psychosis in Ethiopia to improve outcomes
UKHLS: Understanding Society & BHPS
UP'S: A Cohort Study on Recovery in Psychotic Disorder Patients
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In this pocket, we highlight 30 datasets with in-depth assessment of mental health conditions other than depression, anxiety and psychosis.
ADVANCE Armed Services Trauma Rehabilitation Outcome Study
Afghanistan Mental Health and Childhood Adversities
Airwave Health Monitoring Study
Australian Gulf War Veterans’ Health Study Cohort
Biological pathways of risk and resilience in Syrian refugee children (BIOPATH)
Brisbane Longitudinal Twin Study
Building a New Life in Australia (BNLA)
Edinburgh Study of Youth Transitions and Crime
Impact of the Treatment of PTSD on Comorbid Insomnia and Pain
LOGIC (Longitudinal Outcomes of Gender Identity in Children)
Michigan State University Twin Registry (MSUTR)
Millennium Cohort Study (USA military)
National Research Council Twin Registry (NAS-NRC Twin Registry)
Prechter Longitudinal Study of Bipolar Disorder
Seeding Success data resources
Stress in Pregnancy (SIP) Study
Taiwan Birth Cohort Study (TBCS)
The Project Positive Adolescent Training through Holistic Social (PATHS) Programs
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In this pocket, we highlight 82 datasets exemplary for their longevity and repeated assessment of mental health conditions.
3D Cohort Study (Design, Develop, Discover) (3D)
Airwave Health Monitoring Study
Amsterdam Born Children and their Development (ABCD) Study
Australian Longitudinal Study of Women’s Health
Avon Longitudinal Study of Parents and Children (ALSPAC)
Birth to Twenty Plus (Birth to Thirty)
Born in Guangzhou Cohort Study (BIGCS)
Boston University Twin Project (BUTP)
Brisbane Longitudinal Twin Study
British Cohort Study 1970 (BCS70)
British Columbia Generations Project (BCGP)
California Families Project (CFP)
Canadian DOHaD Cohort Registry
Child Health and Development Study (CHDS)
Continuation of Dating It Safe: A Longitudinal Study on Teen Dating Violence
Costa Rican Longevity and Healthy Aging Study
Course and Outcome of Bipolar Youth (COBY)
Dutch ‘TRacking Adolescents’ Individual Lives’ Survey’, TRAILS
English Longitudinal Study of Ageing (ELSA)
Environmental Risk Longitudinal Twin Study (E-Risk)
Great Smoky Mountain Study (GSMS)
Growing Up in Australia (the Longitudinal Study of Australian Children)
Harvard Pilgrim Health Care Institute Project Viva
Harvard Study of Adult Development
Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Jamaican 1986 Birth Cohort Study
Longitudinal Study of Generations
Longitudinal Surveys of Australian Youth
Mater-University Study of Pregnancy (MUSP)
Mauritius Child Health project
Millenium Cohort Study (USA veterans)
Montreal Heart Institute (MHI) Biobank
National Child Development Study (NCDS)
National Longitudinal Study of Adolescent Health (ADD Health)
National Longitudinal Survey of Mature and Young Women (NLSW)
National Longitudinal Survey of Older and Young Men (NLSM)
National Longitudinal Survey of Youth (NLSY79)
National Longitudinal Survey of Youth (NLSY97)
National Longitudinal Survey of Youth 1979 Child and Young Adult (NLSCYA)
National Research Council Twin Registry (NAS-NRC Twin Registry)
Netherlands Study of Depression and Anxiety (NESDA)
New South Wales Child Development Study (NSW-CDS)
Next Steps (formerly known as LSYPE 1)
Norwegian Mother and Child Cohort Study (MoBa)
Pelotas (Brazil) Birth Cohort Study - 1982
Pelotas (Brazil) Birth Cohort Study - 1993
Personality and Total Health Through Life
Project Talent Twin and Sibling Study
Taiwan Birth Cohort Study (TBCS)
Ten to Men (the Australian Longitudinal Study on Male Health)
Twins Early Development Study (TEDS)
UKHLS: Understanding Society & BHPS
Victorian Adolescent Health Cohort Study
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In this pocket, we highlight 27 datasets that focus specifically on groups with liability for developing mental ill health.
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Adolescents at High Risk for Familial Bipolar Disorder
ADVANCE Armed Services Trauma Rehabilitation Outcome Study
Alcohol and Other Drug Treatment Services National Minimum Data Set (AODTS NMDS)
Australian Gulf War Veterans’ Health Study Cohort
Biological pathways of risk and resilience in Syrian refugee children (BIOPATH)
Boston Hospital Workers Health Study (BHWHS)
Brazilian High Risk Cohort Study
British Autism Study of Infant Siblings (BASIS)
Child Protection National Minimum Data Set (CP NMDS)
C-MaMiE: Child outcomes in relation to Maternal Mental disorders in Ethiopia
Danish High Risk and Resilience Study
Desenvolvimentu Isin-d’iak Labarik no Inan (DILI) birth cohort study
Etiological and Prospective Family Study in Southwestern Pennsylvania
Health and Wellbeing of UK Armed Forces Personnel: A Cohort Study
iBerry study: a longitudinal cohort study of adolescents at high risk of psychopathology
Longitudinal Studies on Child Abuse and Neglect (LONGSCAN)
Michigan Longitudinal Study (UMICH)
Millennium Cohort Study (USA military)
National Youth in Transition Database (NYTD)
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In this pocket, we highlight 23 datasets targeting groups typically underrepresented in epidemiological research.
Adolescent Brain Cognitive Development (ABCD) Study
Aetiology and Ethnicity in Schizophrenia & Other Psychoses (AESOP-10)
California Families Project (CFP)
Cambridge Centre for Attention, Learning and Memory
Family and Community Health Study FACHS (FACHS)
First Episode of Psychosis cohort
Fragile Families & Child Wellbeing Study
Generations: A Study of the Life and Health of LGB People in a Changing Society
Healthy Living in an Urban Setting (HELIUS)
Healthy Young Men’s (HYM) study
Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
Life and Living in Advanced Age: a Cohort Study in New Zealand (LiLACS NZ)
LOGIC (Longitudinal Outcomes of Gender Identity in Children)
Resilience, Ethnicity & Adolescent Mental Health (REACH)
Seeding Success data resources
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In this pocket, we highlight 15 datasets from locations rarely represented in longitudinal research.
Africa, the Middle East & Asia
Alliance for Maternal and Newborn Health Improvement (AMANHI) biobanking study
Afghanistan Mental Health and Childhood Adversities
Desenvolvimentu Isin-d’iak Labarik no Inan (DILI) birth cohort study
LIFE course study in CARdiovascular disease Epidemiology (LIFECARE)
Malawi Longitudinal Study of Families and Health (MLSFH)
Mauritius Child Health project
Performance Monitoring for Action (PMA) project
West Africa Birth Cohort Study
Americas
Growth and Obesity Chilean Cohort Study (ECO)
Jamaican 1986 Birth Cohort Study
Jamaican 2011 Birth Cohort Study
Europe & the Pacific
Cross-regional
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In this pocket, we highlight 32 datasets with valuable data on the mental health of ageing populations.
10 K: a large‐scale prospective longitudinal study in Israel
Amirkola Health and Ageing Project (AHAP)
Australian Longitudinal Study of Women Health
Brazilian longitudinal study of aging [ELSA-Brazil]
British Cohort Study 1970 (BCS70)
Canadian Longitudinal Study on Aging (CLSA)
China longitudinal ageing study
Concord Health and Ageing in Men Project - CHAMP
English Longitudinal Study of Ageing (ELSA)
Health and Ageing in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI)
Health and Employment After Fifty Study (HEAF)
Health and Retirement Study (HRS)
Health, Aging and Retirement Transitions in Sweden - HEARTS
Irish Longitudinal Study on Ageing (TILDA)
Mexican Health and Aging Study
National Child Development Study (NCDS)
National Social Life, Health, and Ageing Project (NSHAP)
National Survey of Health and Development (NSHD)
Panel on Health and Ageing of Singaporean Elderly (PHASE)
Personality and Total Health Through Life
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In this pocket, we highlight 18 datasets that will offer rich possibilities for mental research in the future.
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Alliance for Maternal and Newborn Health Improvement (AMANHI) biobanking study
Assessment from Preschool to Puberty—Longitudinal Epidemiological (APPLE) study in Hirosaki, Japan
British Autism Study of Infant Siblings (BASIS)
GUIDE (Growing Up In Digital Europe: EuroCohort)
Mutaba’ah—Mother and Child Health Study
SCOPE: Studying the sociocultural context of psychosis in Ethiopia to improve outcomes
Shanghai Children’s Health, Education and Lifestyle Evaluation, Preschool (SCHEDULE-P) study
Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study)
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In this pocket, we highlight 25 datasets that have detailed measures of a range of risk factors and collected repeated measures of mental health throughout participants lives, including early measurement prior to onset of the conditions.
3D Cohort Study (Design, Develop, Discover) (3D)
Adolescent Brain Cognitive Development (ABCD) Study
Amsterdam Born Children and their Development (ABCD) Study
Avon Longitudinal Study of Parents and Children (ALSPAC)
Birth to Twenty Plus (Birth to thirty)
Child and Adolescent Twin Study in Sweden (CATSS)
Christchurch Health and Development Study
Environmental Risk (E-Risk) Longitudinal Twin Study
Great Smoky Mountain Study (GSMS)
Growing Up in Australia (the Longitudinal Study of Australian Children)
Triple B Pregnancy Cohort Study
Trondheim Early Secure Study (TESS)
Twins Early Development Study (TEDS)
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In this pocket, we highlight 17 datasets that provide windows to the brain through neuroimaging techniques such as magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI) and structural fMRI.
Adolescent Brain Cognitive Development (ABCD) Study
Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Nathan Kline Institute – Rockland Sample (NKI-RS)
National Consortium on Alcohol and Neurodevelopment in Adolescence
Reproducible Imaging-Based Brain Growth Charts for Psychiatry
Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study)
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In this pocket, we highlight 22 datasets that have used wearables and phone apps to collect data.
Adolescent Brain Cognitive Development (ABCD) Study
Amsterdam Born Children and their Development (ABCD) Study
Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology
Feasibility and Acceptability of a Smartphone App to Assess Early Warning Signs of Psychosis Relapse
GEMRIC Linköping, Sweden center
GEMRIC Utrecht, the Netherlands center
Mood Disorder Cohort Research Consortium (MDCRC)
NIMH Intramural Longitudinal Study of the Endocrine and Neurobiological Events Accompanying Puberty
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In this pocket, we highlight 67 datasets with biological and/or genetic data.
23andMe - The Affective disorders, Environment, and Cognitive Trait (AFFECT) study
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Adolescent Brain Cognitive Development (ABCD) Study
Alliance for Maternal and Newborn Health Improvement (AMANHI) biobanking study
Australian Temperament Project
Avon Longitudinal Study of Parents and Children (ALSPAC)
Borealis Biobank of Northern Finland
Born in Guangzhou Cohort Study (BIGCS)
Boston University Twin Project (BUTP)
Canadian Healthy Infant Longitudinal Development (CHILD) Study
Children's Hospital of Philadelphia (CHOP) Biorepository
Copenhagen Aging and Midlife Biobank (CAMB)
Dutch ‘TRacking Adolescents’ Individual Lives’ Survey’; TRAILS
Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Environmental Risk Longitudinal Twin Study (E-Risk)
Estonian Biobank of the Estonian Genome Center
Finnish Clinical Biobank Tampere
Genetic and Environmental Predictors of Combat-Related PTSD
Great Smoky Mountain Study (GSMS)
GROUP (Genetic Risk and Outcome of Psychosis)
Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort study
Health Outcomes and Measures of the Environment (HOME) study
Minnesota Twin Family Study (MTFS)
Montreal Heart Institute (MHI) Biobank
National Child Development Study (NCDS)
National Longitudinal Study of Adolescent Health (ADD Health)
Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)
Norwegian Mother and Child Cohort Study (MoBa)
Qatar Biobank population based cohort study
Sequence Bio - NL Genome Project (pilot study)
Tohoku Medical Megabank Community Cohort Study
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In this pocket, we highlight 36 datasets with routinely collected data.
Administrative Data Research (ADR) UK - Northern Ireland
Agenzia Regionale di Sanità della Toscana (ARS)
Atlantic Partnership for Tomorrow’s Health Study, or Atlantic PATH
Born in Guangzhou Cohort Study (BIGCS)
British Columbia Generations Project (BCGP)
Centre for Data and Knowledge Integration for Health (CIDACS)
Clinical Record Interactive Search System (CRIS)
DANLIFE: Danish LifeCourse Study
Growing Up in Australia (the Longitudinal Study of Australian Children)
Health and Employment After Fifty (HEAF) Cohort
Manitoba Multigenerational Cohort
Mental Health Services Data Set (MHSDS)
National Income Dynamics Study (NIDS)
Next Steps (formerly known as LSYPE 1)
Norwegian Life Course, Ageing and Generation Study (NorLAG)
Norwegian Mother and Child Cohort Study (MoBa)
Puberty Cohort in the Danish National Birth Cohort (DNBC)
Seeding Success data resources
Swedish Longitudinal Occupational Survey of Health (SLOSH)
Texas Department of Criminal Justice
Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study)
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In this pocket, we highlight 39 datasets that include measures of mental health in hand with detailed measurement of participants’ social context.
Belfast Youth Development Study
Born in Bradford: Better Start
Building a New Life in Australia (BNLA)
California Families Project (CFP)
Centre for Data and Knowledge Integration for Health (CIDACS)
China Family Panel Studies (CFPS)
China Health and Nutrition Survey
Chinese Longitudinal Healthy Longevity and Happy Family Study (CLHLS-HF)
Family and Community Health Study (FACHS)
Growing Up in Australia (the Longitudinal Study of Australian Children)
Health and Ageing in Africa: A Longitudinal Study of an INDEPTH Community in South Africa (HAALSI)
Indonesian Family Life Survey (IFLS)
Integrated Data Infrastructure
Journeys Home: a Longitudinal Study of Factors Affecting Housing Stability
Longitudinal Surveys of Australian Youth
Malawi Longitudinal Study of Families and Health (MLSFH)
Mexican Family Life Survey - Mexican Health and Aging Study (MHAS)
National Income Dynamics Study (NIDS)
Norwegian Life Course, Ageing and Generation Study (NorLAG)
Panel Study of Income Dynamics (PSID)
Performance Monitoring for Action (PMA) project
Social Protection Survey [Encuesta de Previsión Social]
Survey of Income and Program Participation Series
Swedish Longitudinal Occupational Survey of Health (SLOSH)
Taiwan Birth Cohort Study (TBCS)
Ten to Men (the Australian Longitudinal Study on Male Health)
UKHLS: Understanding Society & BHPS
Understanding the lives of adolescents and young adults (UDAYA)
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In this pocket we highlight 28 datasets with data for testing the impact of the pandemic on mental health and the long-lasting consequences of viral infection.
Adolescent Brain Cognitive Development (ABCD) Study
British Cohort Study 1970 (BCS70)
Chilean Maternal & Infant Cohort Study II (CHiMINCs-II)
Danish National Birth Cohort (DNBC) - COVID-19 collection
Generation Scotland (incl STRADL)
The Irish Longitudinal Study on Ageing (TILDA)
Loddon Mallee Healthcare Worker Covid Study
National Child Development Study (NCDS)
National Survey of Health and Development (NSHD)
Next Steps (formerly known as LSYPE 1)
Pelotas (Brazil) Birth Cohort Study - 2015
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In this pocket, we highlight 22 datasets that have strong links with other datasets or are part of consortia.
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Ageing Trajectories of Health – Longitudinal Opportunities and Synergies (ATHLOS) project
Asian Pharmacoepidemiology Network (AsPEN)
CanPath, including Alberta’s Tomorrow Project
Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO)
Dutch ‘TRacking Adolescents’ Individual Lives’ Survey’, TRAILS
Dynamic Analyses to Optimize Ageing (DYNOPTA) Project
E3N and E3N-Generations Cohorts
Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Global ECT-MRI Research Collaboration (GEMRIC)
Integrated Data Infrastructure
Next Steps and Our Future
Research Advancement through Cohort Cataloguing and Harmonization (ReACH)
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In this pocket, we highlight 4 datasets with distinctive potential to investigate mental health conditions related to natural disasters or political issues, in situ.
Afghanistan Mental Health and Childhood Adversities
Biological pathways of risk and resilience in Syrian refugee children (BIOPATH)
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In this pocket, we highlight 21 datasets with interventions embedded in their protocol.
Accelerating Medicines Partnership Program - Schizophrenia (AMP-SCZ)
Andhra Pradesh Children and Parents Study
Comparing Effectiveness of Treating Depression With & Without Comorbidity to Improve Fetal Health
Early Developmental Stages of Psychopathology Study
GEMRIC Linköping, Sweden center
GEMRIC Utrecht, the Netherlands center
Measuring Health and Well-being of Young People in the Transfer Project